Bad reaction of vitamin A

Bad reaction of vitamin A
Vitamin A VitA (Retinol) Characteristic of the bad reaction Acute poisoning has taken place eating the polar bear rich in vitamin A, after the big flounder or liver of the shark, its dosage is a million units. Its characteristic, in order to think to sleep, have a headache agitatedly and seriously, be dull, vomit, look at the papilla edema suddenly, take off the bits 24 hours later. As offering higher day at the time of the dosage, toxic symptom appears quickly. Take in 1 millionu toxicity to present from one day to one week every day; Japan take in poison symptom within 1- 36 months by 40- 70 u Wan; Daily intaking amount 15-20 u Wan, produce the poison within 6~85 months. Toxic frequentness and severity generally relate to the individual's vitamin situation, vitamin A of liver stores the low individual, it is a little better than the individual in the normal level to take in the situation of vitamin A of high dosage. The development of the toxic symptom relates to many kinds of factors, such as liver storage, age, protein taking in and one's own disease,etc.. It is enough to cause chronic vitamin A to take in 10,000u long-term every day. It is 30- 150u/ dl that normal serum hits the density of vitamin A, increase to 200- 600u/ d1, is uncertain too and the range or severity which is poisoned symptom is parallel. The main symptom of chronic poisoning is as follows, bone, arthralgia, skin, lip dry or split open, generate heat, the intersection of whole body and discomfort, have a headache, skin take off bits, pruritus and erythema and a kind of dermatitis, emotional tired, urinate increase, night, particularly very, vomit, suffer from abdominal pain, lose the appetite, depilate, the skin presents orange patch around the sole, palm, nose, lip, can also cause liver toxicity to react, the inner high pressure of cranium, look at the papilla edema, hypomenorrhea, the high pressure of portal vein, haemolysis, anaemia, child's epiphysis is closed in early days. Poisoned symptom and relieved after medicines stopped, can last several weeks.Cardiovascular system There are persons who takes place tachycardia of report, may continue the hair generating heat.Nervous system The intersection of acute poisoning and for think, sleep, not sluggish easy to defy, make, not different to resist to have a liking for sleep on, serious headache and look at papilla edema and reply looking at symptom. Chronic vitamin A is poisoned 50% of the craniums patients and pressed and risen, the change with the skin and hair sometimes, the muscle skeleton system pains and tired. Can cause central nervous system symptom such as acute spiritual symptom with vitamin A 3 millionu every day, the pathology of changing with the obvious electroencephalogram and cerebrospinal fluid (CSF) changes. Offered low dose of spiritual inhibitor after medicines stopped, spiritual symptom disappears within l week. Take in vitamin A 1~2 u Wan, amount to 2 year every day, take place in the benign cranium pigeonholing, rising, being dizzy and looking at papillaing edema. Should spend several appear these complication month in infant.Digestive system Acute poisoning is common and disgusting and vomiting and losing the appetite, and there is lip doing and forming a scab, gums inflammation and bleeding. There are persons who takes place polyamine. See that there are liver, spleen and lymph node that become old in the adult. If take in vitamin A for a long time, even if is the regular dosage, may cause the serious hepatocyte to damage. What has been hepatitis appearsed and it is biochemical with symptom change of index, can't with infecting, explain liver supersession and immune system disorderlily. Symptom that the liver damages includes liver great, unusual biochemical index, portal vein high pressure and cirrhosis. Some chronic vitamin A poison patient, make liver, live, examine, 2 see, have liver fiber take and a large number of store the intersection of lipid and cell, assemble around the sinus, fiber take cause blood flow to be insufficient around the the intersection of liver and sinus, might result in, continue person who send hepatocyte wither and the intersection of afterbirth and the intersection of thick liquid and vacuole take shape. Histology is checked to find too the centre vein is hardened and the cooking stove is congested and stored up with the fat around the liver sinus. A lot of evidences indicate liver sinus cells accumulate vitamin A, and involve the nerve fibre. 1 woman amount to 4 year with u Wan, A9 of vitamin, every day, liver live examine, find cell to store fat become heavy and number increase and vitamin A getting green since the body fluoro fades fast. One employs heavy dose of (270,000u)s for a long time Vitamin A treats psoriasis, not merely see reversible chronic poisoning changes, and see it is disorderly that there are reversible door pulse and high pressure and liver function, but there is no cirrhosis on histology to change. But 1 adult employ vitamin A700 u7 long week in Wan, cirrhosis will happen 3 years later, that is because vitamin A in cell which stores lipid around the liver sinus deposits the reason of increasing. Urinary system Chronic poisoning can present many urine, polyuria, urinary incontinence, enuresis and acute kidney caused by renal tubule necrosis to decline. Hematopoietic system Heavy dose of vitamin A can reduce the stability on the floor of low albumen border of the erythrocyte, and cause haemolysis and anaemia. Also can be seen and have neutral cell reducing, leucocyte increasing, blood platelet reducing, regenerated obstacle anaemia and erythrocyte sedimentation rate to increase fast. Endocrine, supersession It may be an early symptom that period is reduced at the time of chronic poisoning, can also cause hypercalcemia disease, hyperglycemia, alkaline phosphatase rises, serum lipid rises, low albumen blood disease, low thrombinogen disease, serum amino transferase raise and serum hit vitamin C reduce, albumen of cerebrospinal fluid (CSF) content reduced and the hydroxyproline increases, calcium increases in the urine in the urine. Chronic poisoning is seen sometimes there is edema.Special sense organ The report happens nystagmic and replying and looks at, is afraid all, eyes skin paralysis, retina bleeding and exophthalmos, these are that the cranium press the change due to raising. Some are poisoned the patient and only looked at the hydropic change of papilla.Muscle skeleton system Employ vitamin A in a large amount, because bone katogene increase, can cause bone little Liang and cortex absorption is accelerated and then. Alkaline phosphatase is raised, the hydroxyproline density increases and calcium increases and relates to these changes in the urine in the urine in the blood, common bone and arthralgia. Can be seen the bone tenderness and not have other bone symptoms, this may be sent by a companion to have the periosteum increases, the bone is plump, and close too early and cause growing to stop in children's long bone epiphysis. The girl had used the total amount 10,500,000u of vitamin A several months ago 1 15 months, lower extremities and backbone take place
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