Tuberculosis wreaks havoc again How does vaccine hold the first barrier _ general knowledge

Tuberculosis wreaks havoc again How does vaccine hold the first barrier _ general knowledge
Our country neonate inoculate work by Bacillus Calmette-Guerin at the beginning on will it be the fifties last century, Bacillus Calmette-Guerin whether children it plans immune history to be most long inoculating the intersection of number of people and largest vaccine at present. In over the past nearly half a century, Bacillus Calmette-Guerin played an important role in reducing the morbidity of diseases such as children's primary tuberculosis, tuberculosis meningitis, millet one type tuberculosis,etc.. In the face of the wreaking havoc again of tuberculosis, people can't help asking today: Known as " Born in the first stitch " Bacillus Calmette-Guerin last the the first passes of tuberculosis?
Protect the battle of the academy of the result
Bacillus Calmette-Guerin was 1908 French physician's card was American special and beast's physician lay between the blue ox type tubercle bacillus that isolated from ox's milk, after by 13 210 generations to reduce the poison and transplant cultivation, are reduced vaccine (BCG) made of bacterial strain of poisonous tuberculosis by this . There are materials that reveal, since the twenties of last century, global Bacillus Calmette-Guerin has inoculated people's number of times and has already been up to more than 3 billion. Even so, for over 70 years, the academia has protected the dispute of the result and never to Bacillus Calmette-Guerin stopped too. Among them the most noticeable one was the eighties of last century an large-scale international result of study in the southern areas of India revealed, Bacillus Calmette-Guerin can only offer low-level protective action (is only 17% that 15 annual mean protect strength) ,This conclusion has shaken people's confidence to Bacillus Calmette-Guerin. Investigate, most domestic scholars confirm at present, Bacillus Calmette-Guerin can maintain the protection periods of 7 years through a large amount of research.
Chinese biotechnology biologicals director of office of the research institute, medical biological engineering researcher Yan ZiHou of Chengdu of group company introduce, Bacillus Calmette-Guerin is used in the prevention already the past 70 years of tuberculosis, have undoubtedly made great contribution to the threat that the mankind avoided suffering tuberculosis. Generally speaking, it is mainly to restrain the tuberculosis fungus from breeding, sowing scatteredly and infecting focal emergence that Bacillus Calmette-Guerin inoculates the result, can not prevent the person who contacts the tubercle bacillus from infecting. Its direct result is to make the people who has inoculated Bacillus Calmette-Guerin avoid suffering from tuberculosis, the indirect result is to reduce crowd's tuberculosis morbidity. The protective action of Bacillus Calmette-Guerin depends on the difference of the bacillus of molecule prevails in it and locality, the protection properties is strong when the fungus type is similar, the protection properties is weak on the contrary. According to general kind of results for many years in our country, its protection properties is effective.
The market shrinks after the cancellation of multiple cropping
It is reported, our country produces Bacillus Calmette-Guerin since 1993. Bacillus Calmette-Guerin produce all by group, biotechnology of China, (grow group hereafter referred to as,) at present Shanghai Vaccine and Serum Institute and institute of biological products of Chengdu under one's command bear, annual production about 6000~8000 the intersection of people and copy Wan, used in Bacillus Calmette-Guerin that human body inoculate, account for 2/3 of production every year among them. Yan ZiHou tells reporters, because each one of most Bacillus Calmette-Guerin is measured for shares of 10 people, so about 1/3 of the Bacillus Calmette-Guerin is lost and discarded in the course of inoculating, real the intersection of demand and about 50 million the intersection of people and about copy, general kinds of rate 85% about. Our country owned Shanghai, Beijing, Chengdu, 4 institutes of biological products of Lanzhou in common and produced Bacillus Calmette-Guerin in the past, the annual production capacity at that time was slightly higher than now. In 1997, our country revised child Bacillus Calmette-Guerin and inoculated the procedure again, decided to stop the multiple cropping of every age group Bacillus Calmette-Guerin, market demand begins to shrink. In this case, China grew the group to carry on the assessment, arrange in an order to the institute of biological products which produced Bacillus Calmette-Guerin, confirm finally that is produced by Shanghai and Chengdu.
It is reported, Bacillus Calmette-Guerin plans the immune category, the state finance obligates funds to enterprises, so the profit is very low. 2 hundred million came from blood products in the output value of 3 times more than hundred million in Chengdu last year. After enterprises authorize through GMP now, the cost rises by a wide margin, Bacillus Calmette-Guerin does not almost have money that can be made. "I made Bacillus Calmette-Guerin and studied in the past, my research direction was the expansion of the Bacillus Calmette-Guerin use now, Chengdu develop the intersection of Bacillus Calmette-Guerin and many the intersection of candy and the intersection of core and sour oral dosage form, already to market demand obtain the new medicine certificate, it can treat diseases such as asthma, bronchitis,etc.. " Yan ZiHou says.
The expert introduces, our country stops multiple cropping on the basis of three reasons: First the main target that protects for Bacillus Calmette-Guerin is a child, but most tuberculosis patients of children can not produce the tuberculosis fungus at clinic side by side. Inoculating Bacillus Calmette-Guerin can't be cut off and propagated the route, the impact on tuberculosis epidemiology is not big. Second it is limited to act on time the protection of Bacillus Calmette-Guerin, inoculate the protection strength that Bacillus Calmette-Guerin can not increase Bacillus Calmette-Guerin repeatedly. Third reduce the side reaction that Bacillus Calmette-Guerin inoculates.
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