Pathologic _'s general knowledge of of tubercle
Pathology: It can be seen for the gathering of one kind of cells of skin in organizing the section that the granulation of tubercle is swollen, among them there are the nuclear macrophages more, have lymphocytes around, but there is not one kind of pathological changes of cheese. Can see, forgive body in the bubble thick liquid of macrophages, such as ovate Schumann (Schaumann) Small body, a pair of small body (asteroid body) of crystallization and star refracting light . Lung tubercle have illness coming on, become, have more extensive monocyte, macrophage, alveolus inflammation that lymphocyte soaked the beginning in disease, involve the alveolus wall and a quality. It may be dissipated by oneself that the alveolus inflammation and granulation are swollen. But in chronic stage, granulation swollen around fibrous the intersection of master cell and collagen take and not hyaline, become the non- specific fiber. It has no characteristic that swollen tissue morphology of the granulation displays, it is obvious in branched bacillus and fungal infection, it is the tissue of foreign matter or traumatism that reacts, also can be seen at beryllium disease, syphilis of third, lymphoma and other source alveolus inflammation of allergy,etc., should walk and distinguish. But see the same tissue pathological change in many organs, combine the clinical materials, can diagnose a disease.
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Monday, January 28, 2013
Pathologic _'s general knowledge of of tubercle
Pathologic _'s general knowledge of of tubercle
Pathology: It can be seen for the gathering of one kind of cells of skin in organizing the section that the granulation of tubercle is swollen, among them there are the nuclear macrophages more, have lymphocytes around, but there is not one kind of pathological changes of cheese. Can see, forgive body in the bubble thick liquid of macrophages, such as ovate Schumann (Schaumann) Small body, a pair of small body (asteroid body) of crystallization and star refracting light . Lung tubercle have illness coming on, become, have more extensive monocyte, macrophage, alveolus inflammation that lymphocyte soaked the beginning in disease, involve the alveolus wall and a quality. It may be dissipated by oneself that the alveolus inflammation and granulation are swollen. But in chronic stage, granulation swollen around fibrous the intersection of master cell and collagen take and not hyaline, become the non- specific fiber. It has no characteristic that swollen tissue morphology of the granulation displays, it is obvious in branched bacillus and fungal infection, it is the tissue of foreign matter or traumatism that reacts, also can be seen at beryllium disease, syphilis of third, lymphoma and other source alveolus inflammation of allergy,etc., should walk and distinguish. But see the same tissue pathological change in many organs, combine the clinical materials, can diagnose a disease.
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Pathology: It can be seen for the gathering of one kind of cells of skin in organizing the section that the granulation of tubercle is swollen, among them there are the nuclear macrophages more, have lymphocytes around, but there is not one kind of pathological changes of cheese. Can see, forgive body in the bubble thick liquid of macrophages, such as ovate Schumann (Schaumann) Small body, a pair of small body (asteroid body) of crystallization and star refracting light . Lung tubercle have illness coming on, become, have more extensive monocyte, macrophage, alveolus inflammation that lymphocyte soaked the beginning in disease, involve the alveolus wall and a quality. It may be dissipated by oneself that the alveolus inflammation and granulation are swollen. But in chronic stage, granulation swollen around fibrous the intersection of master cell and collagen take and not hyaline, become the non- specific fiber. It has no characteristic that swollen tissue morphology of the granulation displays, it is obvious in branched bacillus and fungal infection, it is the tissue of foreign matter or traumatism that reacts, also can be seen at beryllium disease, syphilis of third, lymphoma and other source alveolus inflammation of allergy,etc., should walk and distinguish. But see the same tissue pathological change in many organs, combine the clinical materials, can diagnose a disease.
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Check _'s treatment in the laboratory test of tubercle
Check _'s treatment in the laboratory test of tubercle
Tubercle (sarcoidosis) It is the granulation swollen disease that a kind of multi system many organs are given much trouble. Infringe lung, dual the intersection of side and the intersection of lung and the intersection of door and lymph node, 90% of the above changes with lung at being clinical often, skin and pathological change of eyes secondly, shallow the intersection of table and lymph node, liver, spleen, kidney, bone marrow, nervous system, heart,etc. whole body can be given much trouble nearly. Disease this one limit disease, most good prognosis since, have the tendency to relieve naturally.
First, blood are checked
Activity develop issue can have leucocyte reduce and anaemia, erythrocyte sedimentation rate increase soon. Nearly there is a serum globulin part of about 1/ 2 of patients that increases, the persons who increase with IgG see more, secondly it is IgG, IgM that increase more rarely. The plasma albumin is reduced. Blood calcium increases, the serum uric acid increases, serum alkaline phosphatase increases. Angiotensin invertase of serum (SACE) Activity acute issue increase ' The normal value is 17.6-34u/ml) ,Consult meanings, lie between in vain plainly serum - 2 receptors (IL- 2R) It is plain to lie between solubility in vain- 2 receptors (sIL- 2R) Rise, have comparatively important meaning to diagnosis of tubercle. Also can a1- resist trypsin, dissolve the intersection of fungus and, enzyme? 2- Little globulin '? 2- MG) , serum adenosine desaturase (ADA) , the fiber links albumens(Fn) Wait for, raise, have, consult the meaning while being sure at clinic.
Second, tuberculin test
About 2/ 3 of the tubercle patients test the reactionless or extremely weak response to the skin of 100u tuberculin.
Third, tubercle antigen (Kveim) Test
Organize, make, mix, hang liquid as antigen by 1:10 physiological saline with acute the intersection of tubercle and lymph node or spleen of patient. Fetch, mix, hang the intersection of liquid and 0.1-0.2ml, make intradermal injection, inject appear mauve papule after the 10 day, 4- spread to 3- 8mm 6 weeks later, it is swollen to form the granulation, it is the positive reaction. The skin which excises the positive reaction organizes diagnosis, the positive rate is 75% - 85% Left and right sides. There is 2% - 5% of the false positive reaction. Because without standard antigen, so it is restricted to employ, are eliminated gradually in recent years.
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Tubercle (sarcoidosis) It is the granulation swollen disease that a kind of multi system many organs are given much trouble. Infringe lung, dual the intersection of side and the intersection of lung and the intersection of door and lymph node, 90% of the above changes with lung at being clinical often, skin and pathological change of eyes secondly, shallow the intersection of table and lymph node, liver, spleen, kidney, bone marrow, nervous system, heart,etc. whole body can be given much trouble nearly. Disease this one limit disease, most good prognosis since, have the tendency to relieve naturally.
First, blood are checked
Activity develop issue can have leucocyte reduce and anaemia, erythrocyte sedimentation rate increase soon. Nearly there is a serum globulin part of about 1/ 2 of patients that increases, the persons who increase with IgG see more, secondly it is IgG, IgM that increase more rarely. The plasma albumin is reduced. Blood calcium increases, the serum uric acid increases, serum alkaline phosphatase increases. Angiotensin invertase of serum (SACE) Activity acute issue increase ' The normal value is 17.6-34u/ml) ,Consult meanings, lie between in vain plainly serum - 2 receptors (IL- 2R) It is plain to lie between solubility in vain- 2 receptors (sIL- 2R) Rise, have comparatively important meaning to diagnosis of tubercle. Also can a1- resist trypsin, dissolve the intersection of fungus and, enzyme? 2- Little globulin '? 2- MG) , serum adenosine desaturase (ADA) , the fiber links albumens(Fn) Wait for, raise, have, consult the meaning while being sure at clinic.
Second, tuberculin test
About 2/ 3 of the tubercle patients test the reactionless or extremely weak response to the skin of 100u tuberculin.
Third, tubercle antigen (Kveim) Test
Organize, make, mix, hang liquid as antigen by 1:10 physiological saline with acute the intersection of tubercle and lymph node or spleen of patient. Fetch, mix, hang the intersection of liquid and 0.1-0.2ml, make intradermal injection, inject appear mauve papule after the 10 day, 4- spread to 3- 8mm 6 weeks later, it is swollen to form the granulation, it is the positive reaction. The skin which excises the positive reaction organizes diagnosis, the positive rate is 75% - 85% Left and right sides. There is 2% - 5% of the false positive reaction. Because without standard antigen, so it is restricted to employ, are eliminated gradually in recent years.
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Sunday, January 27, 2013
The intersection of tubercle and the intersection of disease and cause of disease and have illness coming on the intersection of mechanism and the intersection of _ and general knowledge
The intersection of tubercle and the intersection of disease and cause of disease and have illness coming on the intersection of mechanism and the intersection of _ and general knowledge
The mechanism with having illness coming on of the cause of disease: The cause of disease is not so obvious. Infected the factor correctly ' For instance bacterium, virus, mycoplasma, fungi,etc.) Observe, has not obtained the precise conclusion. Carry on research to the inherent cause too, fail to verify. The author finds in the tubercle patient the tubercle bacillus DNA positive rate reaches 50% with PCR technology in recent years, so it is that the branched bacillus invades the result organized to put forward tubercle, but a lot of experiments have not verified this argument. The importance that the majority think cell immunological function and humoral immunological function disorder are tubercle has illness coming on in the mechanism now. A certain ' Some) Cause it under the stimulus of the antigen of tubercle, the macrophages(Am) in the alveolus Activated with T4 cells. Released the leucocyte by Am activated to lie between plainly- 1( IL- 1) ,IL- 1 is a kind of very strong lymphocytic factor, can stimulate lymphocytes and release IL- 2, make T4 cells increase at double and under the function of the lymphokine, make B lymphocytes activate, release immunoglobulin (Ig), the function of one's own antibody is hyperfunction. The lymphocytes activated can release monocyte factor, leucocyte of hastening and melting to inhibit factor and macrophage from moving the conduct and inhibiting the factor. The monocyte trends towards the factor of melting to make the monocyte in the blood around assemble to the quality among the alveolus continually, tubercle the density is nearly 25 times of the blood in his alveolus at the disease. Under a lot of unknown antigen and function of the medium, T lymphocytes, the monocyte and macrophage,etc. are soaked in the alveolus, form the early stage of of tubercle - -Alveolus inflammation stage. With the development of pathological change, the cell composition of alveolus inflammation is reducing constantly, and macrophages are derivatized have one kind of cells of skin to increase gradually, in the granulation that he formated and secreted is swollen stimulates the factor (granuloma-inciting factor) ,etc. function under,it is cheese for tubercle swollen in granulation in disease to be typical without being formed gradually. On later stage, the fiber that release macrophages links plain(fibronectin, Fn)s Can attract becoming fibrous cells (Fb) of a large number of ,Make it and ground substance adhere to outside the cell, in addition, what macrophage secrete become fibrous the intersection of cell and growth factor (growth factor of fibroblasts, GFF) ,Impel into fibrous cells and count and increase; Meanwhile, inflammation and immune cell around so that disappear while further reducing, and cause the extensive fiber of the lung.
In a word, antigen and the cell immunity of organism and result that the humoral immunological function contends each other that tubercle is unknown. Because of the individual's difference ' Age, gender, race, inherent cause, hormone, HLA) With the immunoreactive regulating action of antibody, look at its promotion factor produced and resist the out-of-balance state between the factors short of moneyly, and determine the swollen development of granulation and disappear, demonstrate tubercle different pathologic state and trend that the nature relieves.
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The mechanism with having illness coming on of the cause of disease: The cause of disease is not so obvious. Infected the factor correctly ' For instance bacterium, virus, mycoplasma, fungi,etc.) Observe, has not obtained the precise conclusion. Carry on research to the inherent cause too, fail to verify. The author finds in the tubercle patient the tubercle bacillus DNA positive rate reaches 50% with PCR technology in recent years, so it is that the branched bacillus invades the result organized to put forward tubercle, but a lot of experiments have not verified this argument. The importance that the majority think cell immunological function and humoral immunological function disorder are tubercle has illness coming on in the mechanism now. A certain ' Some) Cause it under the stimulus of the antigen of tubercle, the macrophages(Am) in the alveolus Activated with T4 cells. Released the leucocyte by Am activated to lie between plainly- 1( IL- 1) ,IL- 1 is a kind of very strong lymphocytic factor, can stimulate lymphocytes and release IL- 2, make T4 cells increase at double and under the function of the lymphokine, make B lymphocytes activate, release immunoglobulin (Ig), the function of one's own antibody is hyperfunction. The lymphocytes activated can release monocyte factor, leucocyte of hastening and melting to inhibit factor and macrophage from moving the conduct and inhibiting the factor. The monocyte trends towards the factor of melting to make the monocyte in the blood around assemble to the quality among the alveolus continually, tubercle the density is nearly 25 times of the blood in his alveolus at the disease. Under a lot of unknown antigen and function of the medium, T lymphocytes, the monocyte and macrophage,etc. are soaked in the alveolus, form the early stage of of tubercle - -Alveolus inflammation stage. With the development of pathological change, the cell composition of alveolus inflammation is reducing constantly, and macrophages are derivatized have one kind of cells of skin to increase gradually, in the granulation that he formated and secreted is swollen stimulates the factor (granuloma-inciting factor) ,etc. function under,it is cheese for tubercle swollen in granulation in disease to be typical without being formed gradually. On later stage, the fiber that release macrophages links plain(fibronectin, Fn)s Can attract becoming fibrous cells (Fb) of a large number of ,Make it and ground substance adhere to outside the cell, in addition, what macrophage secrete become fibrous the intersection of cell and growth factor (growth factor of fibroblasts, GFF) ,Impel into fibrous cells and count and increase; Meanwhile, inflammation and immune cell around so that disappear while further reducing, and cause the extensive fiber of the lung.
In a word, antigen and the cell immunity of organism and result that the humoral immunological function contends each other that tubercle is unknown. Because of the individual's difference ' Age, gender, race, inherent cause, hormone, HLA) With the immunoreactive regulating action of antibody, look at its promotion factor produced and resist the out-of-balance state between the factors short of moneyly, and determine the swollen development of granulation and disappear, demonstrate tubercle different pathologic state and trend that the nature relieves.
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Which common symptoms does tubercle have? 's symptom
Which common symptoms does tubercle have? 's symptom
Tubercle is various in clinical manifestation, lack the specificity. Nearly 40% of the cases do not have clinical symptom, find abnormality only during physical examination. The disease is slow that most patients get up, symptom is slight, common symptom is as follows,
1.Non- specific whole body symptom is tired and unable, low-heat, night sweating, lose the appetite, the weight is lightened, muscles and the joint pain etc.. The disease is worried that the specific patient gets up, shown as generating heat, nodular erythema and joint pain, namely Lofgren syndrome, see more the young women patient in gestational period or nursing period.
2.Respiratory system symptom, mainly for the dry cough and uncomfortable in chest. There is a chest that aches, takes the blood even spits blood in the phlegm individually. Shortness of breath is usually caused by the fiber or swollen lung essence pathological change of the granulation after the activity. While developing into an extensive lung fiber, shortness of breath is aggravated, even cyanosis, breathe depletedly.
3.The disease skin sufferer of the skin tag accounts for 11%. The nodular erythema is the most common. A kind of lupus of hemorrhoid is relatively common too, shown as the purple patch pieces of the nose, cheek, ear.
4.Eyes eyes tubercle accounts for 21%. Accompany the eye to be uncomfortable, pain and eyesight obstacle. Chronic pathological change can develop to lose one's sight. It is mainly iris cilliary inflammation. It is acute to be can also be shown as and combine membrane inflammation and dryness cornea conjunctivitis. Can erupt cataract simultaneously and continue taking place glaucoma in later period. The previous grape and membrane inflammation, parotitis and facial nerve paralysis, call Heerfordt's syndrome jointly.
5.Nervous system tubercle can nearly involve any part of the nervous system, account for 8%. Can have the intersection of cranium and nerve paralyse, nerve myopathic, take the intersection of location and the intersection of and pathological change, the intersection of granulation and getting swollen meningitis,etc. in the cranium. The facial nerve paralysis is the most common, most facial nerve paralysis are the single side, account for 65%. Involve hypothalamically or the leaf can cause diabetes insipidus behind the hypophysis.
6.Heart the intersection of tubercle and disease can infringe cardiac muscle directly, form heart granulation swollen or fiber take pathological change, but does not usually display symptom. If there is symptom that is shown as tachycardia, block, congestive and in heart failure more. Can be shown as the arrhythmia even ' Mostly the room) , the angina pectoris, room wall tumour, repeated pericardium accumulate the liquid or die suddenly. Can cause the room arrhythmia of the mortality with the hypercalcemia disease person. Tubercle causes lung worry to see in the serious lung fiber.
7.Renal tubercle can cause calcium nephropathy, cause the renal function to be depleted finally. General high blood calcium take place on serious disease and pathological change giving much trouble the intersection of range and wider case.
8.Lymphocytic tubercle infringes the lymph node around and accounts for 75% around, can be on any position of the body, besides infringing the lung door, mediastinal lymph node, see more most with the oblique angle skin of right side.
9.Skeleton muscle system Can have osteoporosis, the intersection of bag and kind or change and hand at the appearance too ' Foot) Mean out of shape and point ' Toe) First is malnutritive. Arthritis meet on 5%-37% patient, have symmetry and characteristic to visit person who move, and often heal by oneself, usually no structural destruction will take place, will not leave over dysarthrosis. The granulation of muscle is too swollen to often have symptom, often invading and chest muscle, shoulder muscle and sura skin. The intersection of tubercle and disease can also be accompanied and taken place gout.
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Tubercle is various in clinical manifestation, lack the specificity. Nearly 40% of the cases do not have clinical symptom, find abnormality only during physical examination. The disease is slow that most patients get up, symptom is slight, common symptom is as follows,
1.Non- specific whole body symptom is tired and unable, low-heat, night sweating, lose the appetite, the weight is lightened, muscles and the joint pain etc.. The disease is worried that the specific patient gets up, shown as generating heat, nodular erythema and joint pain, namely Lofgren syndrome, see more the young women patient in gestational period or nursing period.
2.Respiratory system symptom, mainly for the dry cough and uncomfortable in chest. There is a chest that aches, takes the blood even spits blood in the phlegm individually. Shortness of breath is usually caused by the fiber or swollen lung essence pathological change of the granulation after the activity. While developing into an extensive lung fiber, shortness of breath is aggravated, even cyanosis, breathe depletedly.
3.The disease skin sufferer of the skin tag accounts for 11%. The nodular erythema is the most common. A kind of lupus of hemorrhoid is relatively common too, shown as the purple patch pieces of the nose, cheek, ear.
4.Eyes eyes tubercle accounts for 21%. Accompany the eye to be uncomfortable, pain and eyesight obstacle. Chronic pathological change can develop to lose one's sight. It is mainly iris cilliary inflammation. It is acute to be can also be shown as and combine membrane inflammation and dryness cornea conjunctivitis. Can erupt cataract simultaneously and continue taking place glaucoma in later period. The previous grape and membrane inflammation, parotitis and facial nerve paralysis, call Heerfordt's syndrome jointly.
5.Nervous system tubercle can nearly involve any part of the nervous system, account for 8%. Can have the intersection of cranium and nerve paralyse, nerve myopathic, take the intersection of location and the intersection of and pathological change, the intersection of granulation and getting swollen meningitis,etc. in the cranium. The facial nerve paralysis is the most common, most facial nerve paralysis are the single side, account for 65%. Involve hypothalamically or the leaf can cause diabetes insipidus behind the hypophysis.
6.Heart the intersection of tubercle and disease can infringe cardiac muscle directly, form heart granulation swollen or fiber take pathological change, but does not usually display symptom. If there is symptom that is shown as tachycardia, block, congestive and in heart failure more. Can be shown as the arrhythmia even ' Mostly the room) , the angina pectoris, room wall tumour, repeated pericardium accumulate the liquid or die suddenly. Can cause the room arrhythmia of the mortality with the hypercalcemia disease person. Tubercle causes lung worry to see in the serious lung fiber.
7.Renal tubercle can cause calcium nephropathy, cause the renal function to be depleted finally. General high blood calcium take place on serious disease and pathological change giving much trouble the intersection of range and wider case.
8.Lymphocytic tubercle infringes the lymph node around and accounts for 75% around, can be on any position of the body, besides infringing the lung door, mediastinal lymph node, see more most with the oblique angle skin of right side.
9.Skeleton muscle system Can have osteoporosis, the intersection of bag and kind or change and hand at the appearance too ' Foot) Mean out of shape and point ' Toe) First is malnutritive. Arthritis meet on 5%-37% patient, have symmetry and characteristic to visit person who move, and often heal by oneself, usually no structural destruction will take place, will not leave over dysarthrosis. The granulation of muscle is too swollen to often have symptom, often invading and chest muscle, shoulder muscle and sura skin. The intersection of tubercle and disease can also be accompanied and taken place gout.
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Tubercle is checked " Four songs " 's general knowledge
Tubercle is checked " Four songs " 's general knowledge
Tubercle (Sarcoidosis) Also calling one kind of tumours of meat has names such as one kind of tumour Schaumann benign lymphocytic granulation swollen diseases of Boeck meat and Besnier and a kind of lupus of hemorrhoid,etc.. It is a kind of chronic granulation swollen disease. Solid to have broken to have the intersection of skin and damage of subjective symptoms also can invade mucous membrane, lymph node, skeleton, organ inside the body and claim the intersection of whole body and sarcomatous disease outside while being routed. Tubercle is whole body disease, most patients anaemia, the leucocyte, blood platelet are reduced in the blood, have a liking for his erythrocyte and increase. Acute issues of erythrocyte sedimentation rate increase fast, chronic issues of serum globulin increase. - 2, and globulin increase obviously. When the liver or skeleton is damaged, serum alkaline phosphatase often increases. It is usually positive that it is tested that cephalin is agglutinate. High blood calcium accounts for 1/3.
1.The great majority of tuberculin test, for the feminine gender or weak and positive.
2.Invertase of angiotensin (angiotensin conkerting enzyme; ACE) Determination
Lieberman points out activity patient's serum ACE level of of a tubercle increases notably. ACE is that a kind of existence combines the glycoprotein in the membrane of lung capillary endothelial cells, can enable the blood vessel usually turn angiotensin 2 on function into stepping up nervously, make blood pressure increase.
3.X-ray examination
The lung door lymph node is often swelling in order to reveal the change of the characteristic lung. The lamination of lung increases thickly, the shade of point-like and tubercle. Carry the phalange and can see the spongy cavity to damage far.
4. if you can't test Kvein not to be, react unusually a cell immunities specific.
The method is as follows: Under operating aseptically, mash the tissue of the tubercle lymph node, dilute with physiological saline into 1: After density 10, filter with the gauze, filtrate and sterilize for two hours at 60 , after aerobic and detest oxygen training and guinea pig and inoculate and confirm aseptically, accede to equal amount of stone charcoal sour physiological saline, dilute to suck 0.25% of the sour antigen of stone charcoal, at the time of the test, 0.1-0.2ml antigen injects covers inside the forearm inside, 6 weeks later, are injecting the position and making skin and living and examining, if have typical the intersection of tubercle and disease, pathology change as positive. The tubercle patient tests the positive rate and more than 90% to Kvein. The false positive rate of healthy people and other disease patient is very low, only accounts for 6.5%, so this test diagnoses value is very high. As disease is relieved, this test can be transferred to negatively.
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Tubercle (Sarcoidosis) Also calling one kind of tumours of meat has names such as one kind of tumour Schaumann benign lymphocytic granulation swollen diseases of Boeck meat and Besnier and a kind of lupus of hemorrhoid,etc.. It is a kind of chronic granulation swollen disease. Solid to have broken to have the intersection of skin and damage of subjective symptoms also can invade mucous membrane, lymph node, skeleton, organ inside the body and claim the intersection of whole body and sarcomatous disease outside while being routed. Tubercle is whole body disease, most patients anaemia, the leucocyte, blood platelet are reduced in the blood, have a liking for his erythrocyte and increase. Acute issues of erythrocyte sedimentation rate increase fast, chronic issues of serum globulin increase. - 2, and globulin increase obviously. When the liver or skeleton is damaged, serum alkaline phosphatase often increases. It is usually positive that it is tested that cephalin is agglutinate. High blood calcium accounts for 1/3.
1.The great majority of tuberculin test, for the feminine gender or weak and positive.
2.Invertase of angiotensin (angiotensin conkerting enzyme; ACE) Determination
Lieberman points out activity patient's serum ACE level of of a tubercle increases notably. ACE is that a kind of existence combines the glycoprotein in the membrane of lung capillary endothelial cells, can enable the blood vessel usually turn angiotensin 2 on function into stepping up nervously, make blood pressure increase.
3.X-ray examination
The lung door lymph node is often swelling in order to reveal the change of the characteristic lung. The lamination of lung increases thickly, the shade of point-like and tubercle. Carry the phalange and can see the spongy cavity to damage far.
4. if you can't test Kvein not to be, react unusually a cell immunities specific.
The method is as follows: Under operating aseptically, mash the tissue of the tubercle lymph node, dilute with physiological saline into 1: After density 10, filter with the gauze, filtrate and sterilize for two hours at 60 , after aerobic and detest oxygen training and guinea pig and inoculate and confirm aseptically, accede to equal amount of stone charcoal sour physiological saline, dilute to suck 0.25% of the sour antigen of stone charcoal, at the time of the test, 0.1-0.2ml antigen injects covers inside the forearm inside, 6 weeks later, are injecting the position and making skin and living and examining, if have typical the intersection of tubercle and disease, pathology change as positive. The tubercle patient tests the positive rate and more than 90% to Kvein. The false positive rate of healthy people and other disease patient is very low, only accounts for 6.5%, so this test diagnoses value is very high. As disease is relieved, this test can be transferred to negatively.
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Which tubercle are to behave and how to diagnose? 's general knowledge
Which tubercle are to behave and how to diagnose? 's general knowledge
[Clinical manifestation ]
Tubercle is a kind of whole body granulation swollen disease, involve skin and a lot of internal organs. The position given much trouble has lung, vertical diaphragm and lymph node, phalange, cardiac muscle, central nervous system, liver, spleen, kidney, eyes and parotid gland around besides skin. Tubercle disease can infringe one organ or organization only, can also many kinds of organ or organization are infringed meanwhile. The condition passes slowly, relieve and recur and replace. The clinical symptom of this disease is varied.
1.Skin display skin, tubercle of disease show as many kinds of shape, often for papule, tubercle, the intersection of spot and piece, red the intersection of skin and ill, silver the intersection of bits and disease kind, one kind of tumours of scar meat, the pigment fails and the bald head is damaged.The cover is decreased and distributed over places such as face and four limbs,etc. asymmetrically. It is flexible that it is touched that rash is hard, expand under the cover gradually, involve the thickness of the whole dermis. The change of the epidermis is not obvious, can become thin, change color slightly, the capillary expands and a few scales bits. It is often rubescent to purple brown, non- routed and broken, there is not subjective symptoms.
(1)One kind of tumours of papule meat is damaged for the syringe needle to the pea size low tubercle, is also called one kind of tumours of grains of meat of millet. Mainly distribute over the face, shank and shoulder. The intersection of glass and block shows faint yellow snack to similar to lupus tubercle, disappear and step back and does not leave the trace while pressing, leave over pigment spot, withers and cicatrix sometimes.
(2)One kind of tumours Hutchinson of piece type meat of spot has reported this unique spot bulk is damaged, as flat and slight high great points of foliate nodular spot pieces that get up of surface at first, common on the cheek, nose and arm.
(3)Often the clear spot piece of border happen on truck and four limbs in one kind of tumours for a kind of meat of silver the intersection of bits and disease, there are scale bits of disease kind of silver bits on it.
(4)Hemorrhoid kinds of lupus type, in take place position of hemorrhoid while being apt, for instance, the intersection of ear and pregnant, cheek portion, nose, mean the intersection of toe and the intersection of and symmetrical blue and green red or mauve spot piece of shallower infiltrations relatively that appear.
(5)The cover plays one kind of tumours of meat and calls one kind of tumours of Darier-Roussy meat too. The bean is to son's big solid skin lower tubercle of millet, with the skin adhesion, the epidermis is presented slightly violet, common on the truck, the face is rare, there is not subjective symptoms.
(6)One kind of tumours of meat of cicatrix is damaged, happened on the scar position. Such as on the scar after burn, folliculitis, herpes zoster. Make the original scar area expand, highly increase, is exactly like the scar hang-up.
(7)Red cover ill type meat infiltration erythema and scale's bits patch of a kind of tumour filling the air distribution, unclear in the border.
(8)Nodular erythema the intersection of meat and kinds of the intersection of tumour and some patient, disease of tubercle, arthralgic companion generate heat and erythrocyte sedimentation rate increase soon in order to person who occur frequently, enlargement of lymph nodes of X-ray examination lung door. The face, back and four limbs stretch the side and happen scatteredly at pain skin lower tubercle. The skin of surface is ruddy, most common to young women.
(9)Mucomembranous meat a kind of tumour buccal hard jaw, cheek department, hanging and stopping up hanging down and big papule of amygdaline syringe needle, troop and merge and form the flat spot piece, small tubercle happens in the conjunctiva of eyelid and lachrymal gland.
(10)Other the intersection of skin and the intersection of damage and the intersection of tubercle and disease can it amalgamates to be calm to have the intersection of skin and lower calcium, itch rash, many shape erythema and folliculitis display. Skin wither and horn take excessive increasing or it fails to be can also caused by this disease by pigment.
2.It is the first whole body disease that other organs damage tubercle, besides skin damage, a lot of organs are given much trouble.
(1)The enlargement of lymph nodes of whole body of pathological change of lymph node accounts for 50%. Tubercle disease early to limited to the shank or enlargement of lymph nodes of armpit only often, later on enlargement of lymph nodes of whole body, especially vertical diaphragm and enlargement of lymph nodes of lung door.
(2)Eye damage tubercle eyes are given much trouble and accounted for 25%- 30%, there are iris inflammation, iris cilliary inflammation. The most common one is granulation swollen tubercle of the iris. The lachrymal gland is involved, for the nodular swelling not aching, lachrymal gland pathological change is often with the enlargement of lymph nodes of shank, the gland, salivary gland and parotid gland are involved under the jaw (Mikulicz syndrome) . There can also be conjunctivitis, keratitis, retinitis and look at the nervous lesion, cause and lose one's sight.
(3)It is given much trouble more commonly that the lung damage lung is dirty. X-ray examination is a point-like, strip or flaky shade. Enlargement of lymph nodes of lung door. Early clinical symptom is relatively light, but it is very obvious to check and behave the silk; The anaphase lung fiber is obvious.
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[Clinical manifestation ]
Tubercle is a kind of whole body granulation swollen disease, involve skin and a lot of internal organs. The position given much trouble has lung, vertical diaphragm and lymph node, phalange, cardiac muscle, central nervous system, liver, spleen, kidney, eyes and parotid gland around besides skin. Tubercle disease can infringe one organ or organization only, can also many kinds of organ or organization are infringed meanwhile. The condition passes slowly, relieve and recur and replace. The clinical symptom of this disease is varied.
1.Skin display skin, tubercle of disease show as many kinds of shape, often for papule, tubercle, the intersection of spot and piece, red the intersection of skin and ill, silver the intersection of bits and disease kind, one kind of tumours of scar meat, the pigment fails and the bald head is damaged.The cover is decreased and distributed over places such as face and four limbs,etc. asymmetrically. It is flexible that it is touched that rash is hard, expand under the cover gradually, involve the thickness of the whole dermis. The change of the epidermis is not obvious, can become thin, change color slightly, the capillary expands and a few scales bits. It is often rubescent to purple brown, non- routed and broken, there is not subjective symptoms.
(1)One kind of tumours of papule meat is damaged for the syringe needle to the pea size low tubercle, is also called one kind of tumours of grains of meat of millet. Mainly distribute over the face, shank and shoulder. The intersection of glass and block shows faint yellow snack to similar to lupus tubercle, disappear and step back and does not leave the trace while pressing, leave over pigment spot, withers and cicatrix sometimes.
(2)One kind of tumours Hutchinson of piece type meat of spot has reported this unique spot bulk is damaged, as flat and slight high great points of foliate nodular spot pieces that get up of surface at first, common on the cheek, nose and arm.
(3)Often the clear spot piece of border happen on truck and four limbs in one kind of tumours for a kind of meat of silver the intersection of bits and disease, there are scale bits of disease kind of silver bits on it.
(4)Hemorrhoid kinds of lupus type, in take place position of hemorrhoid while being apt, for instance, the intersection of ear and pregnant, cheek portion, nose, mean the intersection of toe and the intersection of and symmetrical blue and green red or mauve spot piece of shallower infiltrations relatively that appear.
(5)The cover plays one kind of tumours of meat and calls one kind of tumours of Darier-Roussy meat too. The bean is to son's big solid skin lower tubercle of millet, with the skin adhesion, the epidermis is presented slightly violet, common on the truck, the face is rare, there is not subjective symptoms.
(6)One kind of tumours of meat of cicatrix is damaged, happened on the scar position. Such as on the scar after burn, folliculitis, herpes zoster. Make the original scar area expand, highly increase, is exactly like the scar hang-up.
(7)Red cover ill type meat infiltration erythema and scale's bits patch of a kind of tumour filling the air distribution, unclear in the border.
(8)Nodular erythema the intersection of meat and kinds of the intersection of tumour and some patient, disease of tubercle, arthralgic companion generate heat and erythrocyte sedimentation rate increase soon in order to person who occur frequently, enlargement of lymph nodes of X-ray examination lung door. The face, back and four limbs stretch the side and happen scatteredly at pain skin lower tubercle. The skin of surface is ruddy, most common to young women.
(9)Mucomembranous meat a kind of tumour buccal hard jaw, cheek department, hanging and stopping up hanging down and big papule of amygdaline syringe needle, troop and merge and form the flat spot piece, small tubercle happens in the conjunctiva of eyelid and lachrymal gland.
(10)Other the intersection of skin and the intersection of damage and the intersection of tubercle and disease can it amalgamates to be calm to have the intersection of skin and lower calcium, itch rash, many shape erythema and folliculitis display. Skin wither and horn take excessive increasing or it fails to be can also caused by this disease by pigment.
2.It is the first whole body disease that other organs damage tubercle, besides skin damage, a lot of organs are given much trouble.
(1)The enlargement of lymph nodes of whole body of pathological change of lymph node accounts for 50%. Tubercle disease early to limited to the shank or enlargement of lymph nodes of armpit only often, later on enlargement of lymph nodes of whole body, especially vertical diaphragm and enlargement of lymph nodes of lung door.
(2)Eye damage tubercle eyes are given much trouble and accounted for 25%- 30%, there are iris inflammation, iris cilliary inflammation. The most common one is granulation swollen tubercle of the iris. The lachrymal gland is involved, for the nodular swelling not aching, lachrymal gland pathological change is often with the enlargement of lymph nodes of shank, the gland, salivary gland and parotid gland are involved under the jaw (Mikulicz syndrome) . There can also be conjunctivitis, keratitis, retinitis and look at the nervous lesion, cause and lose one's sight.
(3)It is given much trouble more commonly that the lung damage lung is dirty. X-ray examination is a point-like, strip or flaky shade. Enlargement of lymph nodes of lung door. Early clinical symptom is relatively light, but it is very obvious to check and behave the silk; The anaphase lung fiber is obvious.
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