Early genetic mechanism's _ symptom that cancer of colon takes place

Early genetic mechanism's _ symptom that cancer of colon takes place
It shows in a research that U.S.A.'s national science develops on the network edition of the magazine in November of this year to issue, chromosome might prior to tumour, inhibit genetic inactivation while being unstable, it may early mechanism that cancer of colon take place.

Martin A of the advanced technological research institute of Princeton. Dr. Nowak points out, have already known the earliest distributing rectal cancer of knot had illness coming on the mechanism has been that tumour inhibits genetic APC (adenoma is a kind of colon polyp) at present Gene mutation.

But discover, there is unstable (CIN) chromosome in the mouse cells with APC gene mutation ,CIN is not because APC gene mutation causes. Because it is difficult to confirm the emergence time of CIN, researchers developed a kind of mathematical model and studied and formed the dynamic change that rectal cancer has illness coming on. The parameter of this mathematical model includes: Mutation rate gene, dominant CIN number, normal and CIN cell heterogeneity disappears number of cells in the colon gland with dangerous pathological change,etc. before breeding potential, cancer of rate, CIN nucleus APC-/ - cell.

Dr. Nowak supposes the important function of CIN is the disappearance rate which increases genetic heterogeneity, moreover, because CIN can impel the lose that tumour inhibit the gene second from being copied, so, CIN is the early mechanism of the canceration.

Find until large parameter choose in the range very, need, 5 take place, can make CIN prior to APC gene mutation, lead to the fact the cell canceration to 25 CIN only finally, this means cancer of colon takes place that may be started by CIN in fact. Nowak Dr. think, can find CIN that appear frequently in the intersection of regression and the intersection of colon and gland that change, will prove the above-mentioned hypothesis.
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