High-pressure _'s general knowledge of lung artery of desmosis relevance

High-pressure _'s general knowledge of lung artery of desmosis relevance
Desmosis is a kind of one's own immune disease based on blood vessel and chronic inflammation of the connective tissue, mainly involve the joint and soft tissue around, including muscle, tendon, ligament, slippery membrane, muscle membrane,etc.. Filling the air desmosis mainly includes systemic lupus erythematosus, rheumatoid and arthritis, simulator sickness of the primary dry interconnected system, multiple myositis and leather myositis, vascular inflammation of systemic sclerosis, systematicness, mixing desmosis, overlap syndrome, not splitting up desmosis,etc. They can happen in various clans and every age crowd, the pathogenic factor is not clear. Have one's own immunity, vascular inflammation and chronic inflammation of connective tissue are that its common basic pathology changes. Desmosis is much damaged systematically, the existence that can often measure many kinds of one's own antibodies in serum, it is one of the main reasons for deformity. The artery type artery high pressure of lung is paid attention to day by day desmosis' erupting simultaneously, the emergence of the artery high pressure of lung has already become one of the suggestions of desmosis with bad prognosis.
The morbidity mechanism of desmosis and relevant lung artery high pressure is still not totally clear, desmosis may cause endothelial cells, blood vessel smooth muscle cells and become proliferating state and function and taking place unusually of fibrous cells. Lung the intersection of artery and endothelial cell have, produce nitrous oxides and forefront the intersection of ring and the intersection of relaxation and blood vessel such as being plain material and inner skin to shrink the intersection of blood vessel and function of material, under the normal condition, the expressions and production of these two kinds of materials are in a kind of equilibrium state, and is maintaining the stability of the artery. When the stimulus and the function appears that endothelial cells receive the relevant factor of desmosis is unusual, the production of relaxation and blood vessel material reduces and shrinks the expression of the blood vessel material to increase, the easy disorder of drawing back the function of lung artery leads to the fact the lung is arteriolar to present chronically and is blocked, therefore cause the forming of the artery high pressure of lung.
The intersection of lung and arterial pressure rise, prove, have 70% the intersection of lung and blood vessel damage at least, namely lung dirty to store function to be obviously limited, so should prevent from and is infected, gives up smoking, forbids and reduces weight medicine and codeine, avoids gestation and plateau environment actively. Hormone and immune inhibitor are often used for treating desmosis sent originally, but find clinically its curative effect differs significantly in different desmosis, brief on though they belong to desmosis, but they may not be all the same in continuing and taking place the mechanism of artery high pressure of lung. Not having illness coming on in the mechanism at present yet very clear specifically of various desmosis relevance lung artery high pressure, so should be each with particular emphasis in treating.
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