Disgusting therapeutic _'s treatment that vomits due to toxic medicine of cell

Disgusting therapeutic _'s treatment that vomits due to toxic medicine of cell
Cao CaiSheng Shang RongXin 2005-12-13 13:07:00 China's practical medical magazine Number 15 of Vol. 4 of August of 2004

Medicine of any chemotherapy can irritate and kill the leather cells at a large amount of digestive tract mucous membrane active in hyperplasia while wounding tumour cells, stimulate bringing (CTI) to automatic nervous system and after brain chemosensitive receptor Function; The lighter causes patient's appetite to drop, the heavy one causes violently and disgustingly to vomit. Many patients refuse chemotherapy and influence the treatment of disease, so it is particularly important to prevent the emergence of the chemotherapy medicine side effect. Vomiting that the chemotherapy medicine causes relates to medicine kind, dosage, relate to age, gender, individual difference, cause and spit the more seriously obeying ammonia platinum of chlorine of function, amide enzyme of L-17 winter, the actinomycetes is plain,
1 prevent and cure the intersection of cell and the intersection of poisonous substance and medicine that quality due to vomit while being daily
Vomiting that the medicine causes divides sending vomiting and taking place vomiting late early, especially sending vomiting is more difficult treatment late, must discern that cause other reasons vomited. There are the following several kinds of medicines that due to poisonous substance quality vomits to often use for preventing and curing cells.
1.1 Tell piperazine (s phenthiazines) General stupid the intersection of chlorine and piperazine, spit, come, resist, chlorpromazine, three Fluorine draw piperazine, perphenazine, 3 chlorpromazine,etc., it is the dopamine receptor which block the centre that their end spits the function mechanism. Piperazine 5- 10mg of general stupid chlorine, time of every 4h or 8h1, oral administration or skin note: Chlorpromazine 25mg, 2-3 times a day, oral administration or skin note.
1.2 Man benzene acyl (butyrophenones) Such as Fluorine piperazine pyridine, Fluorine piperazine pyridine alcohol, it is the dopamine receptor that resists pharmaceuticals short of moneyly too. Fluorine piperazine pyridine 1- 2mg, time of every 6h or 8h1, oral administration or skin note; Fluorine piperazine pyridine alcohol 0.5- 1mg, every 3- 4h1 time, intramuscular injection.
1.3 Alkali of the hemp (camabinodi) Such as four hydrogen hemp phenol, can inhibit vomiting the centre directly, and can inhibit prostaglandin from formating, it is better to stop vomiting the result than piperazine of general stupid chlorine. Four hydrogen hemp phenol 5- 10mg/m 2, every 3- 4h1 time, take orally.
1.4 Dynamics medicine of intestines and stomach ( 1) It is derivative of Procaine amide to kill and spit fairy, it acts on the centre and acts on the intestine too, mainly receive the body [1 ] through inhibiting dopamine D 2 of the chemosensitive receptor district of after brain, and produce and stop vomiting function, kill, spit fairy, have 5 - HT 2 receptor resist, act on while being short of money also while being heavy dose of, general the intersection of consumption and 0.15mg/kg, stop, spit result to be poor, heavy dose of 1- 3mg/kg, stops vomiting the result to obviously strengthen, but there is nervous system symptom after heavy dose of quiet note. ( 2) Much Pan sets up ketone [2 ]: Block pharmaceuticals for the peripheral dopamine receptor, act on the gastrointestinal tract directly, increase the sphincter tension in the gullet underpart, increase the stomach and wriggle, promote the stomach to empty, it is disgusting and vomiting to inhibit, 10mg time, 3-4 times a day, take orally. ( 3) Xisha must profit act on neural clump under intestines, promote release of acetyl choline, thus regulate the sports of intestines and stomach. Can reduce the esophagus, stomach, duodenum backflow. Its function begins 30- 60min, 5- 10mg time after taking orally, take orally, 3 times a day.
1.5 Steroid hormone [3]( steroids) Through resisting inflammation, resisting allergic function and lightening the gastrointestinal tract and reacting. ( 1) Fill in on rice a 10mg quiet without being loosed some,6h1 time, be amounted to 4 times. ( 2) The intersection of methyl and quiet note, 125- 250mg of Meticortelone, every through 3- 6h1 time, amount to 4 times.
1.6 Resist ergamine and resist choline and act on to inhibit the centre through the centre, and stop vomiting calmly, diphenhydramine 20- 40mg skin note once, phenergan 25mg skin note.
1.7 The stable type gives play to and stops spitting the effect 5- 10mg time by inhibition of the centre, oral administration or skin note.
1.8 5 - the intersection of hydroxy and the intersection of color and the intersection of amine and the intersection of and receptor can resist medicine [4 ] highly alternative binding with 5 of the intestinal centres - HT 3 receptor while being short of money, block the reflex arc vomited, produce and stop vomiting function. This kind of medicine is effective fast, and there is no poisonous side effect of extrapyramidal system. ( 1) The pivot would rather reply ' Red west ketone of domestic kindness) 8mg adds into 100ml liquid a bit more quietly. ( 2) Dose draws department Joan (granisetron) 1mg, 2 times d, take orally. ( 3) Hold the red department Joan (ondemsetron) high 8mg, 2 times d, quiet note. ( 4) Dora department Joan (dolasetron) 10mg, takes orally once d, 20mg function is stronger. ( 5) Hold the alkane department Joan (tropisetron) 5- 10mg/d.
1.9 Vitamin B6 participates in the supersession of amino acid and fat and lightens the intestines and stomach and reacts, 300mg, it is a bit quieter to enter the liquid, once day.
2 medicines unite function in order to lighten the side effect and improve and resist and vomit curative effect, often several kinds of medicines unite application, commonly used union scheme: ( 1) The pivot would rather reply ' Red west ketone of kindness) Chemotherapy 8mg quiet to kill, vomit fairy while being heavy dose of a bit ' 30 after chemotherapy- 50mg is a bit quieter) Unite and use. ( 2) It is single pharmaceutical would rather reply pivot + fill in rice loose + oral administration be lasted fairy to be killed. ( 3) Kill and spit fairy, diphenhydramine, dexamethasone, vomit to resist and share stably. ( 4) Chlorpromazine, Fluorine piperazine are fixed with methyl prednisone combination. ( 5) Heavy dose of fairy 1- 3mg/kg of killing spitting, dexamethasone 20- 40mg, diphenhydramine 50mg. Two kinds of ends spit medicines and unite application, different links that can be vomited contribute, prevent and cure and vomit function and is obviously superior to medicines and use separately.
References
A high China. Pivot reply would rather reply Ann, employ, prevent chemotherapy to be sick to vomit the clinical result, observe jointly with heavy dose of stomach. Magazine of practical internal medicine department of China, 2000, 20( 6) : 373.
2 Lee rues dragon. Poisonous side effect and preventing and curing of lung cancer with therapeutic chemistry. Magazine of practical internal medicine department of China, 1996, 16( 4) : 201-202.
3 Lee shakes. Chemical treatment and immunization therapy of malignant tumour, Beijing: People's Health Publisher, 1990, 14-15.
4 Lee wins it. Take orally 5 - the intersection of hydroxy and the intersection of color and amine - the intersection of and the intersection of receptor and antagonist prevent from whom chemotherapy cause vomit. China's new medicine and clinical magazine, 2002, 21( 11) : 672-674.
Author's unit: 052560 Hebei the intersection of deep marsh and the intersection of county and the intersection of hospital and internal medicine department
Second hospital in Xinji of Hebei
(Accept draft date: 2004-03-30)

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