Succeed in developing and can help new medicine development by albumen laser detection technique of cell membrane

Succeed in developing and can help new medicine development by albumen laser detection technique of cell membrane
It is reported according to the daily scientific net recent report, the researchers of American Vanderburg university develop a new kind of laser technology, can measure reacting each other between protein and other many kinds of biological molecules on the cell membrane. This kind of detection plays an important role while developing the process in the medicine.
Nearly have 7000 kinds of proteins in human cells, among them 30% control the signal of the cell molecule operation mechanism to have 60%-70% to emerge from the albumen of membrane on the cell membrane, so about half the medicines aim at the cell membrane albumen on the market at present. But because the membrane albumen is very difficult to purify, the scientist faces a lot of difficulties while studying their structure. Existing the intersection of detection and membrane means to live in environment, separate the intersection of membrane and albumen from their mostly, or revise like the fluorogenic label in different ways, in order to analyze their activity. These methods are not only expensive while dawdling, but also may influence the function of the goal membrane albumen.
The research group that the biological research institute chemical professor Darryl and Huo Pu in Bonn of Vanderburg's chemistry of the university led cooperates with Scripps research institute, have developed one by name " L And then to the scattering interferometer " (BSI) New for laser technology,last membrane albumen and cohesion between various member in nature.
BSI it is very simple for operation to stand up, mix, pack two molecule into, fill liquid little boxes of microscope by one, shine with a bunch of red laser similar to the scanner of the bar code, can measure the cohesion between them. After the geometirc shape of the small box is adjusted suitably, the laser will be produced and interfered the pattern, and this kind of interference pattern is highly sensitive to response between the molecules. If the molecule begins to act on each other, the pattern begins to vary.
In order to examine the accuracy of BSI, researchers have made a kind of synthetic membrane with GM1 small protein, cholera toxin will enter cells, it is such small protein to mainly combine the target. They mix with membrane the the intersection of cholera toxin and B, the intersection of cohesion and result that detect with identical in result not received with other method. In order to further confirm, they natural to separate film and with one correlated with thymic cancer still 3 and pain, inflammation, nerve transmission plain GABA respectively ' Used for relaxing, sleeping and regulating tensely) Relevant the intersection of protein and membrane examine, combine molecule, mix correspondingly including these proteins membrane, the result received too and by other methods with the value that BSI technology measures is the same.
In addition, this technology has entered commercialization to have a bright future, Vanderburg university has already patented to the new laser detection technique, and already got 3 A approval. They have also specially established a molecule to sense the company to develop the new technology exclusively.

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