Pathologic _'s general knowledge of cause of disease of tubercle

Pathologic _'s general knowledge of cause of disease of tubercle
The mechanism with having illness coming on of the cause of disease: The cause of disease of tubercle is not so obvious. Infected the factor correctly ' For instance bacterium, virus, mycoplasma, fungi,etc.) Observe, has not obtained the precise conclusion. Carry on research to the inherent cause too, fail to verify. The author finds in the tubercle patient the tubercle bacillus DNA positive rate reaches 50% with PCR technology in recent years, so it is that the branched bacillus invades the result organized to put forward tubercle, but a lot of experiments have not verified this argument. The importance that the majority think cell immunological function and humoral immunological function disorder are tubercle has illness coming on in the mechanism now. A certain ' Some) Cause it under the stimulus of the antigen of tubercle, the macrophages(Am) in the alveolus Activated with T4 cells. Released the leucocyte by Am activated to lie between plainly- 1( IL- 1) ,IL- 1 is a kind of very strong lymphocytic factor, can stimulate lymphocytes and release IL- 2, make T4 cells increase at double and under the function of the lymphokine, make B lymphocytes activate, release immunoglobulin (Ig), the function of one's own antibody is hyperfunction. The lymphocytes activated can release monocyte factor, leucocyte of hastening and melting to inhibit factor and macrophage from moving the conduct and inhibiting the factor. The monocyte trends towards the factor of melting to make the monocyte in the blood around assemble to the quality among the alveolus continually, tubercle the density is nearly 25 times of the blood in his alveolus at the disease. Under a lot of unknown antigen and function of the medium, T lymphocytes, the monocyte and macrophage,etc. are soaked in the alveolus, form the early stage of of tubercle - -Alveolus inflammation stage. With the development of pathological change, the cell composition of alveolus inflammation is reducing constantly, and macrophages are derivatized have one kind of cells of skin to increase gradually, in the granulation that he formated and secreted is swollen stimulates the factor (granuloma-inciting factor) ,etc. function under,is it typical to form gradually it is cheese tubercle swollen in granulation in disease. On later stage, the fiber that release macrophages links plain(fibronectin, Fn)s Can attract becoming fibrous cells (Fb) of a large number of ,Make it and ground substance adhere to outside the cell, in addition, what macrophage secrete become fibrous the intersection of cell and growth factor (growth factor of fibroblasts, GFF) ,Impel into fibrous cells and count and increase; Meanwhile, inflammation and immune cell around so that disappear while further reducing, and cause the extensive fiber of the lung.
In a word, antigen and the cell immunity of organism and result that the humoral immunological function contends each other that tubercle is unknown. Because of the individual's difference ' Age, gender, race, inherent cause, hormone, HLA) With the immunoreactive regulating action of antibody, look at its promotion factor produced and resist the out-of-balance state between the factors short of moneyly, and determine the swollen development of granulation and disappear, demonstrate tubercle different pathologic state and trend that the nature relieves.
Pathology: It can be seen for the gathering of one kind of cells of skin in organizing the section that the granulation of tubercle is swollen, among them there are the nuclear macrophages more, have lymphocytes around, but there is not one kind of pathological changes (Fig. of cheese 2- 11- 1) . Can see, forgive body in the bubble thick liquid of macrophages, such as ovate Schumann (Schaumann) Small body, a pair of small body (asteroid body) of crystallization and star refracting light . Lung tubercle have illness coming on, become, have more extensive monocyte, macrophage, alveolus inflammation that lymphocyte soaked the beginning in disease, involve the alveolus wall and a quality. It may be dissipated by oneself that the alveolus inflammation and granulation are swollen. But in chronic stage, granulation swollen around fibrous the intersection of master cell and collagen take and not hyaline, become the non- specific fiber. It has no characteristic that swollen tissue morphology of the granulation displays, it is obvious in branched bacillus and fungal infection, it is the tissue of foreign matter or traumatism that reacts, also can be seen at beryllium disease, syphilis of third, lymphoma and other source alveolus inflammation of allergy,etc., should walk and distinguish. But see the same tissue pathological change in many organs, combine the clinical materials, can diagnose a disease.
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