's symptom of diagnostic method of cancer of colon

's symptom of diagnostic method of cancer of colon
In recent years, the morbidity of cancer of colon of our country rises year by year, diagnose early, find early, and then it is rather important to treat early for patient of cancer of colon. Diagnose abroad at cancer of colon that checks the respect to develop very fast, introduce several kinds as follows now:
A science of heredity is measured:
1. Recently, have published to Dr. Salvatore Siena in Italian Milan about employing science of heredity to check the therapeutic effect of cancer of colon on the magazine network edition of " lancet oncology " Research report,this report point out: Epidermis growth factor receptor (EGFR) Gene copy count, rise, can predict person who shift patient of cancer of colon uses the curative effect against EGFR treatment. Dr. Siena's research group has carried on EGFR and copied the detection that is counted to 10 patients effective in treatment and 21 invalid patients. 8 people EGFR copy and count rising in 9 treatment effective patients, by contrast, 21 invalid patients, only a person EGFR copies and counts rising. Analyze outside the body that shows, can totally block EGFR to copy and count the medicine density of chemotherapy which raises cell hyperplasia of cancer, do not have raised cancer cell that fail to respond to any medical treatment as to EGFR.
2. American Johns? Reports such as Hopkin university Kimmel cancer centre Feinberg of Sri Lankan,etc., the blood of slight change takes place and test and can confirm the degree of danger that cancer of colon has illness coming on through measuring the genetic code.
Relevant research reveals, the seal is lacked (loss of imprinting LOI) Relate to several kinds of cancers. LOI of IGF2 gene exists to the patient of cancer of colon higher than 40%. The purpose that Feinberg,etc. studies is: Does LOI relate to cancer of colon?
This research gathers 172 blood samples doing the colon mirror and examining the patient together. Among them, 25 have cancer of colon and family history of the polyp or have cancer of colon and medical history of the polyp in person, and the blood LOI measures the masculine gender. An of cancer of colon, there was the patient's positive rate of blood LOI mark of family'solon and medical history of the polyp in person, There is positive rate of blood LOI mark of the polyp patient that increases nearly 3.5 times, it is more than 4.4 times without family's history that the positive rate of blood LOI mark of the person who has medical history of cancer of colon increases.
Researchers claim: "It can be like discerning the method of the high-risk group of heart disease that we hope, this test can help us to discern the high-risk group of cancer of colon too, follow up a case by regular visits to and prevent, can help us to diagnose the patient of cancer of colon them in early days at least closely. " But at present in the hereditary mark of this blood is measured and can only be used for studying. Feinberg,etc. say, we might need a lot of years to develop the effective method of inspection.
Two excrement and urine is checked:
Researchers H a r d t of the lucky university hospital full of trees of Germany,etc. find, measure third ketoacid kinase of tumour M 2 (M 2 - P K) in the excrement and urine Can sift and check that forms rectal cancer sensitively.
Whether it has colon tumour that the occult blood test of excrement and urine can be understood indirectly. But this method can't distinguish and bleed whether to come from tumour or other diseases. It's time to discover, among patient of cancer of colon and patient without tumour, tumour M 2 - P K level in the excrement and urine has prominent differences. And very strong relevance exists when sown scatteredly at level and tumour of this enzyme. Adopt the intersection of E L I S A and method measure, have person who contrasts cancer of colon and form the intersection of rectal cancer and the intersection of excrement and urine and sample of patient. Result: Control group M 2 - P K is that (3. 3 0. 4 ) U m l, it is that (5 6 and form the rectal cancer patient. 1 1 5. 3 ) U m l . While determining the normal value as 4 U m l,cancer of colon the 2 Mses of patient - for 14 times of peoples normal in value in P K.
So, the excrement and urine tumour M 2 - P K has measured and offered a kind of very promising new means for forming the rectal cancer and sifting, checking.
Three. Colon mirror checks time
The intersection of university and the intersection of medical college and to have the intersection of cancer of colon and the intersection of family and history S c h o e n f e l d,etc., Michigan of U.S.A., but enteric the intersection of mirror and the intersection of inspection and normal the intersection of colon and mirror of patient reexamine time, go on research, the preliminary result reveals, it was the optimum spacing interval that the high-risk group examine at the same time in 5. But likewise suitable compatriot wait to further study this result.
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