Mobilize pulse and harden treat or have new targets early in lupus erythematosus

Mobilize pulse and harden, treat or have new targets early in lupus erythematosus
It is reported (reporter Hu DeRong) Systemic lupus erythematosus (SLE) Launch the new mechanism in a kind of sclerosis of porridge of pulse to study, make the break-through recently early, relevant the intersection of research and thesis publish in international rheumatism that U.S.A. publish learning field burn the intersection of name and academic publication>. This magazine is here " The leaderette " China claims: "This research will contribute to mobilizing a kind of understanding of sclerosis mechanism of porridge of pulse to SLE early, offer the possible therapeutic target for clinic in the future. " This research is headed the list of signers by the subsidiary rheumatism discipline professor Bao ChunDe of Yan Chai Hospital of Shanghai Communications University medical college.
Atherosclerosis the hair and blood vessel of heart brain incident caused by it early in SLE patient, become, influence the intersection of SLE and patient survive quality and long-term important factor of mortality already. Moreover, inflammatory course and immune disorder existing in SLE course of disease have already consideredded to be the thing SLE patient mobilizes one kind of hardened dangerous factors independently of porridge of pulse early, among them interferon of Model I is one of SLE important pathogenic molecules, and become this research focus with new domain.
Bao ChunDe seminar finds in the study on macrophage source foam cell models of people, after activating in the interferon thorough fare of the Model I, can start the direct regulation and control of the sub district through phosphatide acyl inositol 3 kinase routes and genes, raise macrophage surface lipids and engulf the relevant molecule street cleaner and is expressed by the body A, cause cells to oxidizing the engulfing and increasing of lipoprotein of low density, thus promote the forming of the key composition macrophage source foam cells of one kind of spot pieces of porridge of artery; And peripheral the intersection of blood and the intersection of street cleaner and the intersection of receptor and A in the single nuclear cell, patient of SLE, express too apparent to higher than health control group,
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