The schizophrenia treatment finds the new target some researches and develops and opens up the new way for the medicine
One recently>A thesis of publication of magazine claims, two key links in development of cerebral cortex of DISC1 albumen play an important role, its function can be regulated dynamically. Researchers say, this discovery means the treatment of schizophrenia has new targets that is clicked, to DISC1 It becomes possible that new medicine of the albumen defect is developed.
Schizophrenia is a kind of common spiritual disease, patients will present symptoms such as the illusion, vainlying hope,etc., not only the one that influenced the patient seriously is physical and psychological and healthy, but also increased the society to bear greatly at the same time, influence social stability and economic development . Generally think, schizophrenia relates to cerebral cortex defect, but DISC1 albumen development and function in the cerebral cortex give play to the respect to play an important role again, so it may be mainly exchanging the sense factor of spiritual diseases such as schizophrenia, mood obstacle and self-closing disease,etc.. But to the mechanism of role in spiritual disease of this albumen, not very clear.
An international research group composed of researchers in Great Britain and American and Japan discovers, in two key links of development of cerebral cortex, DISC1 albumen playing an important role, its phosphorylated course functions as molecular switch. The little mouse experiment indicates, DISC1 albumens will keep having hyperplasia of splitting grandfather's cell of silk on one hand, the nerve cell after on the other hand will stimulate silk and split one ing is moved, thus guarantee the normal full play of the brain function. Once the intersection of DISC1 and albumen go wrong, the intersection of cell and hyperplasia and move, can be influenced.
Researcher point out until the intersection of grandfather and the intersection of cell and hyperplasia and nerve cell move relevant regulation mechanism know little about all the time in the cerebral cortex educational circles, the new discovery contributes to remedying this blank. The double function of DISC1 albumen shows in the cerebral cortex, phosphorylation of this albumen is that one of schizophrenia mainly exchanges the sense factor, therefore it clicks as a potential target of schizophrenia treatment. Studies have suggested, the function of DISC1 albumen can be regulated dynamically, this means that it becomes possible to develop a new medicine that can correct DISC1 albumen defect.
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