The systemic lupus erythematosus patient takes rattan _ mineral of impact on mineral density of bone of Thunder God for a long time

The systemic lupus erythematosus patient takes rattan _ mineral of impact on mineral density of bone of Thunder God for a long time

Systemic the intersection of lupus erythematosus and patient take the intersection of Thunder God and the intersection of rattan and impact on mineral density of bone for a long time

Magazine of Chinese dept. of dermatology Vol. 31 of number 1 of 1698 years Treatise

Author: Huang Lan Feng ShuFang Wang HongFu

Unit: 200040 Shanghai medical university Huashan hospital dept. of dermatology [ Huang Lan Feng ShuFang (adviser) ]

Keyword: Lupus erythematosus; Systematicness; The intersection of Thunder God and rattan; Mineral density of bone

[Summary ] Purpose Study, take the intersection of Thunder God and rattan to systemic the intersection of skeleton and influence long-term of system, patient of lupus erythematosus, for a long time.Method Can adopt pair of high sensitivity the measure apparatus of mineral density of bone of X-ray to 71 systemic lupus erythematosus patients and press age, the person who contrasts health that the gender, weight, height mate determines the mineral density of waist vertebra.Result Take the intersection of Thunder God and the intersection of rattan and the intersection of waist and the intersection of vertebra and density, patient of group, drop notably for a long time, the intersection of bone and density its drop the intensity, relate to the fact that totally medicine time. The rattan has prominent influence on systemic lupus erythematosus patient's skeleton system on the conclusion is taken Thunder God for a long time, enable
Take place afterwards on osteoporosis and the dangers of fracture degrees of increase,should last attention of clinician.

The Effect on Bone Mineral Density in SLE Patients after Long-term Administration ofTripterygium Wilf ordii Hook F. Huang Lan, Feng Shufang, Wang hongfu.Departmentof Dermatology, Huashan Hospital,Shanghai Medical University,Shanghai 200040[Abstract]Objective To investigate the effect on skeletal system in SLE patients after long-term administration of Tripte rygium Wilfordii(TW) .Methods The bone mineral density(BMD) of lumbar vertebrae 2- 4 was detected by dual energy X-ray absorptiometry (DXA) with high sensitivity in 71 SLE patients and healthy controls matched with age,sex,

weight and height.Results (1)Long-term administration of TW could significantly decrease BMD level. (2)The degree of this effect was significantly associated with total duration of administration of TW.Conclusion Our data suggest that long-term administration of TW has remarkable effect on skeletal system in SLE patients, and increases the risk rate of

osteoporosis and bone fracture.

[Key words] Lupus erythematosis,systemic Tripterygium wilfordii Bone mineral

density

Take to Thunder God for a long time the chronic poisonous side effect that the rattan can cause every system of whole body, attract people's attention most with the impact on reproductive system particularly[1 , 2 ],But see the literature report about the intersection of Thunder God and rattan to the intersection of skeleton and influence long-term of system so far. So, we can adopt pair of high sensitivity the mineral density of bone of X-ray (abbreviated as the bone density) Systemic lupus erythematosus (SLE) of rattan of Thunder God to taking of the measure apparatus for a long time Patient make the intersection of bone and density determine, find Thunder God rattan have, reduce the intersection of bone and side effect of density notably, report as follows now.

Case and method

A materials

71 SLE patients, 6 men among them, 65 women. 21-65 years old, 42.0 average years olds, the course of disease was from one month to 24, every 8.8 years. The situation is divided into 4 groups according to taking medicine: 17 groups, rattan and cortex steroid hormone (been abbreviated as hormone) for not admiring Thunder God Person; 225 of group, for take the intersection of Thunder God and rattan person while being simple, take rattan crude medicine 45g or Thunder God rattan many glucoside 60mg of Thunder God every day, the medicine time of accumulative total is 1- 20 years; 15 of group, for take hormone person while being simple, take hormone every day quantity for loose and 15mg the above-mentioned to splash Buddhist nun, accumulative total medicine time 0.5; Shanghai medical university institute of radio-medicine [ Wang HongFu (adviser) ]-In 22 years; 14 groups, rattan of Thunder God for taking at the same time or successively and hormone person, it was 0.5- 12 years and 2- 18 year respectively that the two took time totally. 2The rattan according to Thunder God of group is divided into 2 groups medicine time totally: 13 groups A, medicine time is less than or equal to 5 years; 12 groups B, medicine time> is 5 years.

All cases accord with SLE diagnostic standard of ARA in 1982, steady in condition,and except thyroid gland, gland disease, serious liver kidney damage and ovary excising factors influencing bone supersession prominent by first form.

Second, method

Can adopt DPX-L type pair the measure apparatus of bone density of X-ray (the products of U.S.A. Lunar Company) . The resolution ratio of this instrument is good, the sensitivity is high, precision is up to 1%. Person examined fetch lie supine location measure, half crook the intersection of hip and posture, cross lumbar vertebrae, go on, scan, determine. By the intersection of computer and automatic analysis, screen reveal picture, laser printing bone density determines the result.

All patients mate according to the age, gender, weight, height and race person who chooses health contrast, the same measurer measures the lumbar vertebrae (L) 2- 4 bone density values, the resulting bone density difference (indicated by s) after fetching compared with health contrast person Examine t. The comparison among 4 groups, adopt two samples to count t of the difference to examine when variance is neat, t' adopting two samples and counting when variance is not neat examines.

Attached list 4 groups of SLE patients and lumbar vertebrae 2 of person who contrasts health mating- 4

Comparative result of density difference of the bone (g/cm2)





Group

Logarithm

s

T value

P value





Have not taken two medicines group

17

0.018 0.053

1.400

>0.05





Thunder God organizes rattan

25

-0.058 0.110

2.636

? . 05





Splash Buddhist nun's loose group

15

-0.168 0.130

5.005

? . 01





Two medicines share the group

14

-0.202 0.123

6.145

? . 01





Result

First, take the intersection of Thunder God and the intersection of rattan and the intersection of impact on bone density and attached list, reveal, admire the intersection of Thunder God and rattan with the intersection of waist and the intersection of vertebra and the intersection of density and value with control group of the health, patient of group, of hormone, distinguish, and it take for a long time on Thunder God rattan sum (or) 2 of hormone, its bone density value of group are lower than healthy control group, have significance differences on statistics. The rattan is compared with group of hormone with admiring Thunder God, 2 taking medicine, group L2-, 4 bone density values, drop, have the intersection of significance and difference (t' 2.983 - 5.175 - 6.233 respectively in value, P 0.05) .

Second, the intersection of Thunder God and rattan add up to the impact on bone density of medicine time

2In 25 patients of group, the rattan is divided into 2 groups medicine time totally according to Thunder God: Group A, less than or equal to 5 years, 13, 's bone density is - 0.005 0.111g/cm2; Group B, in> 5 years, 12, density value of 's bone is - 0.111 0.072g/cm2. Two groups of comparison, have significance differences (t =2.819,P< 0.05) ,Reveal the bone density drops with Thunder God the rattan adds up to medicine time relevantly, the longer the medicine time is, the bone density drops more prominently.

Discussion

Thunder God rattan have, resist inflammation, immunity, inhibit, be antitumor and resist the intersection of person who bear and function and widely used in clinic with their, at desmosis such as SLE, often take continuously or repeatedly for a long time. Employ the intersection of Thunder God and rattan treat SLE so far, about poisonous side effect its for many kinds of reports will it be latter stage the seventies. ZhaoQi Song, to observe, take the intersection of Thunder God and rattan, symptom control effective rheumatoid arthritis (RA) for a long time especially on Germany The patient's bone joint X-ray changes, find Thunder God the rattan can make shuttleless loom -shaped swelling of the joint lighten, but osteoporosis becomes more serious. But they propose Thunder God rattan it treats RA to be better in recent curative effect, take, can't prevent the intersection of joint and going on destruction of ossicle from for a long time only[2 ]. Lahita puts forward SLE one's own inclination without osteoporosis[3 ],But we observe a part take the intersection of Thunder God and rattan or amalgamate, take the intersection of hormone and the intersection of condition and steady SLE patient, often tell waist having a backache, bone-ache while being simple while being long-term, easy fracture, resist inflammation medicine and fail to respond to any medical treatment, increase the hormone dosage to make symptom become more serious instead for non- steroid, offer active vitamin D3The treatment can relieve symptom. Observe, take the intersection of Thunder God and rattan, make patient's bone density drop for a long time tentatively, drop to 56% of its normal contrast in the same way most seriously. Research this show too at the same time, take the intersection of Thunder God and the intersection of bone and density that rattan cause drop until medicine time obviously relevant. Accumulative total medicine time over 5 the intersection of SLE and patient of year drop more prominently less than the intersection of patient and bone density of 5 year taking medicine. Brief on, need, take the intersection of Thunder God and patient of rattan, want, pay attention to, monitor their bone density value even more for a long time to those reason condition, take the precautionary measures in time, so as to avoid irreversible damage, cause the serious consequence.

This result of study still shows, have side effect which reduce the bone density to take to Thunder God for a long time rattan and hormone, but the intersection of bone and density that cause drop prominent afterwards person, Thunder God rattan have his superiority, it resists the inflammation, immunity on as kind of function of hormone of inhibiting etc., but the poisonous side effect is lighter than hormone. So, so long as the clinician insists that uses medicine clinically rationally, take the corresponding measure to reduce the medicine bad reaction, Thunder God application of rattan should have broader prospect.

References

Unless 1 Feng is sweet-smelling in tree, unless pivots abundant Zheng, there are on Ke Kang,etc.. The intersection of Thunder God and the intersection of rattan and impact on women SLE sex hormone level. The magazine of Chinese dept. of dermatology, 1989, 22: 3-5.

2 auspicious Lin Li, easy Daffyd edits. The intersection of Thunder God and research and clinical practice of rattan. First. Beijing: China Science Tech Publishing House, 1989.207-226,257-258.

3 Lahita RG. Systemic lupus erythematosus. 2nd ed. New york: Churchill, 1692.922-923.

(Accept the draft: 1697-01-14 Build, answer: 1697-10-05)


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