Sand of Xie is smooth and hanging on the general profit of the promise and comparing _'s treatment to the result that the chronic heart declines patient's independent nervous system activity

Sand of Xie is smooth and hanging on the general profit of the promise and comparing _'s treatment to the result that the chronic heart declines patient's independent nervous system activity
In the chronic heart declines patients, the active disorder of independent nervous system will exert a serious influence on the whole course of disease. Have studied and revealed that regulates the renin already - angiotensin - aldosterone system (RAAS) Can strengthen the activity of controlling and can reduce the Epinephrine independently to the heart rate. Italian Barry Dr. Elisabetta De Tommasi and his the colleague, on ACE inhibitor (hang on the general profit of the promise) of the university Resist pharmaceuticals with the intersection of AT1 and short of money receptor ' Sand of Xie is smooth) Decline the intersection of patient and the intersection of heart rate and variability, the intersection of pressure and receptor, reflect sensitivity and the intersection of blood plasma and the intersection of noradrenaline and horizontal different effects, carry on the assessment to chronic heart.
In one pair of blind tests at random, 90 left room ejection fraction lts; 40% of the chronic hearts decline patients (mean age 61 10 years old, heart function 2.3 0.5 grades, according to association's hierarchical standard of the heart of New York) Accept separately that relies the general profit of the promise ' Increase to 20 mg/d gradually) Or Xie sand smooth ' Increase to 160 mg/d gradually) Treat for 16 weeks. Determine the variability of heart rate before and after using medicine ' Guard standard deviation of one) while obtaining normal R-R through the electricity of 24-hour heart , the spontaneous pressure receptor reflects sensitivity and blood plasma aldosterone, noradrenaline level.
Researchers find, sand of Xie is smooth and relies the influence that the general profit of the promise controls to left room function, arterial pressure, blood plasma aldosterone level and heart rate independently not prominent and surprised. Two kinds of medicines can obviously reduce blood plasma noradrenaline level, but the smooth function of Xie sand is more obvious: Xie sand smooth relying the intersection of promise and general profit, can enable the intersection of blood plasma and the intersection of noradrenaline and competence lower by 27% and 6% (Plt respectively; 0.05)
Doctor,etc. thinks, ACE inhibitor (hang on the general profit of the promise) Resist pharmaceuticals with the intersection of AT1 and short of money receptor ' Sand of Xie is smooth) To the absent-minded influence it is similar to control of fan of the heart rate, but through determining blood plasma noradrenaline level finds sand of Xie is smooth nerve function is more obvious to live in regulating sympathetically.
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